When it comes to particle analysis, precision matters. The Envision NTA particle analyzer is leading the charge.

In a recent test, we pushed the boundaries by successfully measuring 30 nm Polystyrene Latex (PSL) particles (Thermo Scientific, 3030A), achieving an incredibly narrow distribution peak at the correct size. These results showcase the Envision’s exceptional lower detection limit, far beyond what most legacy NTA systems can achieve.

For context, most NTA systems struggle to detect particles smaller than 50-70nm, especially for PSL samples. The Envision NTA Particle Analyzer has several design features that extend our lower limit well beyond what other legacy systems are capable of.

Detecting the Smallest Particles, Even in Complex Samples

Perhaps even more impressive is the Envisions ability to accurately size smaller particles despite the presence of larger aggregates. In our initial measurement, larger particles (which tend to be brighter) around 100 nm were present alongside the 30 nm particles. Yet, the Envision was able to distinguish between the different sizes in the distribution.

After removing the aggregates with centrifugation, the 30 nm PSL particles were isolated and measured, as shown in the first graph.

Why The Envision Stands Out

This unmatched sensitivity of the Envision system is a result of the high signal to noise ratio enabled by the lower background noise, advanced optical system and specialized sample cell, providing a clear image and minimizing optical noise from surfaces or optical misalignment. This level of sensitivity doesn’t just apply to particle sizing – it opens up new possibilities for fluorescence-mode experiments as well, making the Envision a versatile tool for a wide range of research applications. Check out our Products page for more information on the Envision. Products 2 – Hyperion Analytical

Ready to push your particle analysis to the next level? Contact us today to explore how the Envision can revolutionize your research. Contact – Hyperion Analytical